The Roles of Circular RNAs in Ischemic Stroke through Modulating Neuroinflammation

Autor: Xin Gu, Lingfei Li, Biao Chen, Yuyao Zhang, Yongji Zhou, Keqin Liu, Wenqin Xia, Xiaoqin Li, Zheng Zhang, Huanqing Shi, Jinyu Huang, Beibei Gao, Lin Jiang, Anwen Shao, Congguo Yin
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Journal of Integrative Neuroscience, Vol 23, Iss 4, p 87 (2024)
Druh dokumentu: article
ISSN: 0219-6352
DOI: 10.31083/j.jin2304087
Popis: Ischemic stroke (IS) remains a serious threat to human health. Neuroinflammatory response is an important pathophysiological process after IS. Circular RNAs (circRNAs), a member of the non-coding RNA family, are highly expressed in the central nervous system and widely involved in regulating physiological and pathophysiological processes. This study reviews the current evidence on neuroinflammatory responses, the role of circRNAs in IS and their potential mechanisms in regulating inflammatory cells, and inflammatory factors affecting IS damage. This review lays a foundation for future clinical application of circRNAs as novel biomarkers and therapeutic targets.
Databáze: Directory of Open Access Journals