Dynamics of Early Establishment of SARS-CoV-2 VOC Omicron Lineages in Minas Gerais, Brazil

Autor: Mariane Talon de Menezes, Filipe Romero Rebello Moreira, Charles Whittaker, Franciele Martins Santos, Daniel Costa Queiroz, Victor Geddes, Paula Luize Camargos Fonseca, Jaqueline Góes de Jesus, Franciane Mendes-Oliveira, Valquíria Reis-Souza, Bibiana Santos, Danielle Alves Gomes Zauli, Aline Brito de Lima, Cristiane de Brito Mendonça, Luige Biciati Alvim, Joice do Prado Silva, Frederico Scott Varella Malta, Alessandro Clayton de Souza Ferreira, Nuno R. Faria, Ester Cerdeira Sabino, Renato Santana Aguiar
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Viruses, Vol 15, Iss 2, p 585 (2023)
Druh dokumentu: article
ISSN: 1999-4915
14691957
DOI: 10.3390/v15020585
Popis: Brazil is one of the nations most affected by Coronavirus disease 2019 (COVID-19). The introduction and establishment of new virus variants can be related to an increase in cases and fatalities. The emergence of Omicron, the most modified SARS-CoV-2 variant, caused alarm for the public health of Brazil. In this study, we examined the effects of the Omicron introduction in Minas Gerais (MG), the second-most populous state of Brazil. A total of 430 Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) samples from November 2021 to June 2022 from Belo Horizonte (BH) city were sequenced. These newly sequenced genomes comprise 72% of all previously available SARS-CoV-2 genomes for the city. Evolutionary analysis of novel viral genomes reveals that a great diversity of Omicron sublineages have circulated in BH, a pattern in-keeping with observations across Brazil more generally. Bayesian phylogeographic reconstructions indicate that this diversity is a product of a large number of international and national importations. As observed previously, São Paulo state is shown as a significant hub for viral spread throughout the country, contributing to around 70% of all viral Omicron introductions detected in MG.
Databáze: Directory of Open Access Journals
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