A technique for quantitative measurement of myocardial blood flow using a combination of bolus tracking and time-registered helical multidetector CT angiography during adenosine stress
| Autor: | Takashi Ichihara, Richard T. George, Richard Mather, Joao A.C. Lima, Albert C. Lardo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: | |
| Zdroj: | Fujita Medical Journal, Vol 1, Iss 1, Pp 9-14 (2016) |
| Druh dokumentu: | article |
| ISSN: | 2189-7247 2189-7255 |
| DOI: | 10.20407/fmj.1.1_9 |
| Popis: | Objectives: The purpose of this study was to develop a quantitative method for myocardial blood flow (MBF) measurement using contrast-enhanced multidetector computed tomography (MDCT) images with bolus tracking and helical scanning. Materials and Methods: Nine canine models of left anterior descending artery stenosis were prepared and underwent MDCT perfusion imaging during adenosine infusion to study a wide range of flow parameters. Neutron-activated microspheres were injected to document MBF during adenosine infusion. Six animals underwent dynamic MDCT perfusion imaging, and K1 and k2 (which represent the first-order transfer constants from left ventricular blood to myocardium and from myocardium to the vascular system, respectively) were measured using a two-compartment model. The results were compared against microsphere MBF measurements, and the extraction fraction (E) of contrast agent and the mean value of k1/k2 were calculated. Six animals then underwent helical CT perfusion imaging, and neutron-activated microspheres were injected to document MBF during adenosine infusion. For each animal, based on E, K1/k2, time-registered helical CT myocardial data, and arterial input function data, tables of myocardial CT values versus MBF were simulated for various MBF values to create look-up tables from the myocardial CT value to MBF. The CT-derived MBF values were compared against the microsphere MBF measurements. Results: A strong linear correlation was observed between the MDCT-derived MBF and the microsphere MBF (y = 1.065x – 0.616, R2 = 0.838). Conclusions: Regional MBF can be measured accurately using a combination of bolus tracking and time-registered helical CT data from contrast-enhanced MDCT scanning during adenosine stress. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|