Controversies in the Interpretation of Liquid Biopsy Data in Lymphoma

Autor: Maria Cristina Pirosa, Sven Borchmann, Fabrice Jardin, Gianluca Gaidano, Davide Rossi
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: HemaSphere, Vol 6, Iss 6, p e727 (2022)
Druh dokumentu: article
ISSN: 2572-9241
00000000
DOI: 10.1097/HS9.0000000000000727
Popis: The rapid evolution of genomic technologies over the last years has led to the development of different methods for the detection, measurement and analysis of cell-free DNA fragments (cfDNA) which are shed into the bloodstream by apoptotic cells and circulate at a low concentration in plasma. In cancer patients, the proportion of tumor-derived cfDNA is defined as circulating tumor DNA. This analysis, commonly known as liquid biopsy, allows to access tumor DNA through a simple blood sampling and therefore without the need of an invasive tissue biopsy. For this reason, this tool may have several clinical applications in terms of diagnosis, prognosis, and monitoring of minimal residual disease. However, there are still several critical issues that need to be resolved. In this review, we will discuss some of the controversies around this method and its potential clinical applications.
Databáze: Directory of Open Access Journals
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