| Autor: |
Hasan Hüseyin Tavukçu, Tarık Emre Şener, Ömercan Albayrak, Özge Çevik, Mehmet Erşahin, Şule Çetinel, Nurdan Bülbül, Göksel Şener |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Journal of Urological Surgery, Vol 5, Iss 2, Pp 98-104 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
2148-9580 |
| DOI: |
10.4274/jus.1909 |
| Popis: |
Objective: Erectile dysfunction is commonly encountered after radical prostatectomy due to cavernous nerve injury (CNI). We investigated the effects of riboflavin (Rb) on bilateral CNI in a rat model. Materials and Methods: Twenty-four male rats were divided into four groups: control (C), patients with bilateral CNI, those with CNI receiving postoperative Rb treatment (CNI+Rb), and those with CNI receiving pre- and post-operative Rb treatment (Rb+CNI+Rb). Bilateral CNI was performed in all groups except for C. The CNI+Rb group was treated with 30 mg/kg Rb daily after CNI for two weeks; the Rb+CNI+Rb group was treated with 30 mg/kg Rb daily one week before CNI and then for two weeks after injury. Mean arterial pressure (MAP) and intracavernosal pressure (ICP) were measured 14 days after CNI in all groups. Tissue malondialdehyde, cyclic guanosine monophosphate, nerve growth factor, superoxide dismutase and total nitric oxide synthase (NOS) activities, neuronal NOS (nNOS) and inducible NOS (iNOS) were analyzed. Results: ICP/MAP ratio was significantly lower in the CNI (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
