Ki-67 Antigen Overexpression Is Associated with the Metaplasia-Adenocarcinoma Sequence in Barrett's Esophagus
| Autor: | Bernardo Silveira Volkweis, Richard Ricachenevsky Gurski, Luise Meurer, Guilherme Gonçalves Pretto, Guilherme da Silva Mazzini, Maria Isabel Edelweiss |
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| Jazyk: | angličtina |
| Rok vydání: | 2012 |
| Předmět: | |
| Zdroj: | Gastroenterology Research and Practice, Vol 2012 (2012) |
| Druh dokumentu: | article |
| ISSN: | 1687-6121 1687-630X |
| DOI: | 10.1155/2012/639748 |
| Popis: | Introduction. The objective of this study was to evaluate Ki-67 antigen expression in patients with Barrett’s esophagus and esophageal adenocarcinoma and to assess its correlation with the metaplasia-esophageal adenocarcinoma progression. Methods. Using immunohistochemistry we evaluated the Ki-67 index in patients with Barrett’s esophagus, esophageal adenocarcinoma, and controls. We included patients with endoscopically visible columnar mucosa of the distal esophagus (whose biopsies revealed specialized intestinal-type metaplasia), patients with esophageal and esophagogastric tumors types I and II, and patients with histologically normal gastric mucosa (control). Results. In the 57 patients studied there were no statistically significant differences between the groups with respect to age or race. Patients with cancer were predominantly men. The Ki-67 index averaged 10±4 % in patients with normal gastric mucosa (n=17), 21±15 % in patients with Barrett’s esophagus (n=21), and 38±16 % in patients with cancer (n=19). Ki-67 expression was significantly different between all groups (P |
| Databáze: | Directory of Open Access Journals |
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