Increased serum carboxylesterase-1 levels are associated with metabolic dysfunction associated steatotic liver disease and metabolic syndrome in children with obesity

Autor: Huanyu Wang, Shimin Wu, Ying Weng, Xi Yang, Ling Hou, Yan Liang, Wei Wu, Yanqin Ying, Feng Ye, Xiaoping Luo
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Italian Journal of Pediatrics, Vol 50, Iss 1, Pp 1-9 (2024)
Druh dokumentu: article
ISSN: 1824-7288
DOI: 10.1186/s13052-024-01733-7
Popis: Abstract Background Carboxylesterase 1(CES1) is expressed mainly in the liver and adipose tissue and is highly hypothesized to play an essential role in metabolism. Our study aimed to investigate the association between CES1 and metabolic syndrome (MetS) and metabolic dysfunction associated steatotic liver disease (MASLD) in children with obesity in China. Methods This study included 72 children with obesity aged 6-13years (including 25(35%) diagnosed as MetS and 36(50%) diagnosed as MASLD). All subjects were measured in anthropometry, serum level of biochemical parameters related to obesity, circumstance levels of insulin-like growth factor1, adipokines (adiponectin, leptin and growth differentiation factor 15) and CES1. Results Higher serum CES1 level were found in the MetS group (P = 0.004) and the MASLD group (P
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