| Autor: |
Pei-Fen Kuan, Xiaohua Yang, Xu Ren, Chang Che, Monika Waszczuk, Roman Kotov, Sean Clouston, Prashant K. Singh, Sean T. Glenn, Eduardo Cortes Gomez, Jianmin Wang, Evelyn Bromet, Benjamin J. Luft |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2158-3188 |
| DOI: |
10.1038/s41398-021-01431-6 |
| Popis: |
Abstract Gene expression has provided promising insights into the pathophysiology of post-traumatic stress disorder (PTSD); however, specific regulatory transcriptomic mechanisms remain unknown. The present study addressed this limitation by performing transcriptome-wide RNA-Seq of whole-blood samples from 226 World Trade Center responders. The investigation focused on differential expression (DE) at the gene, isoform, and for the first time, alternative splicing (AS) levels associated with the symptoms of PTSD: total burden, re-experiencing, avoidance, numbing, and hyperarousal subdimensions. These symptoms were associated with 76, 1, 48, 15, and 49 DE genes, respectively (FDR |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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