| Autor: |
Byung-Yoon Cha, Wen Lei Shi, Takayuki Yonezawa, Toshiaki Teruya, Kazuo Nagai, Je-Tae Woo |
| Jazyk: |
angličtina |
| Rok vydání: |
2009 |
| Předmět: |
|
| Zdroj: |
Journal of Pharmacological Sciences, Vol 110, Iss 1, Pp 105-110 (2009) |
| Druh dokumentu: |
article |
| ISSN: |
1347-8613 |
| DOI: |
10.1254/jphs.08282FP |
| Popis: |
Abstract.: Platelet-derived growth factor (PDGF)-BB is one of the most potent factors in the development and progression of various vascular disorders such as restenosis and atherosclerosis. Chrysoeriol is a flavonoid with antioxidant and anti-inflammatory activities. In this study, we investigated the effect of chrysoeriol on the proliferation of human aortic smooth muscle cells (HASMC). Chrysoeriol significantly inhibited PDGF (20 ng/mL)-induced migration and [3H]-thymidine incorporation into DNA at concentrations of 5 and 10 μM without any cytotoxicity. Chrysoeriol also blocked PDGF-stimulated dissociation of actin filament and inhibited PDGF beta-receptor (Rβ) phosphorylation in a concentration-dependent manner. As a result, the downstream signal transduction pathways of PDGF-Rβ, including ERK1/2, p38, and Akt phosphorylation, were also inhibited by chrysoeriol in the same pattern. These findings suggest that in addition to its antioxidant and anti-inflammatory activities, chrysoeriol may be used for the prevention and treatment of vascular diseases and during restenosis after coronary angioplasty. Keywords:: smooth muscle cell, chrysoeriol, platelet-derived growth factor (PDGF)-induced proliferation, antiproliferative, migration |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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