(2R,6′R,E)-3′-(1-Aminoethylidene)-7-chloro-4,6-dimethoxy-6′-methyl-3H-spiro[benzofuran-2,1′-cyclohexane]-2′,3,4′-trione

Autor:	Boris V. Lichitsky, Andrey N. Komogortsev, Valeriya G. Melekhina
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	griseofulvic acid enaminone acylation Inorganic chemistry QD146-197
Zdroj:	Molbank, Vol 2023, Iss 1, p M1590 (2023)
Druh dokumentu:	article
ISSN:	1422-8599
DOI:	10.3390/M1590
Popis:	A novel synthesis approach for griseofulvin derivatives was developed. The presented method is based on a two-stage process that includes preliminary acetylation of griseofulvic acid followed by condensation with ammonium acetate. The advantages of this protocol include readily available starting materials and a simple target product isolation procedure. The structure of the synthesized polycyclic compound was approved by 1H, 13C-NMR spectroscopy, high-resolution mass spectrometry with electrospray ionization (ESI-HRMS), and X-ray diffraction.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f1f273ea100a437ead6333a36e1c639c Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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