| Autor: |
Supratik Sen Mojumdar, Zackary N. Scholl, Derek R. Dee, Logan Rouleau, Uttam Anand, Craig Garen, Michael T. Woodside |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-017-01996-1 |
| Popis: |
Misfolding of superoxide dismutase 1 (SOD1) is linked to amyotrophic lateral sclerosis. Here the authors characterize the unfolding/refolding of single SOD1 molecules using optical tweezers, identifying partially folded intermediates that lead to misfolding after the formation of a native-like core. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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