| Autor: |
Yamato Fujihira, Yumeng Liang, Makoto Ono, Kazuki Hirano, Takumi Kagawa, Norio Shibata |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Beilstein Journal of Organic Chemistry, Vol 17, Iss 1, Pp 431-438 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1860-5397 |
| DOI: |
10.3762/bjoc.17.39 |
| Popis: |
A straightforward method that enables the formation of biologically attractive trifluoromethyl ketones from readily available methyl esters using the potent greenhouse gas fluoroform (HCF3, HFC-23) was developed. The combination of fluoroform and KHMDS in triglyme at −40 °C was effective for this transformation, with good yields as high as 92%. Substrate scope of the trifluoromethylation procedure was explored for aromatic, aliphatic, and conjugated methyl esters. This study presents a straightforward trifluoromethylation process of various methyl esters that convert well to the corresponding trifluoromethyl ketones. The tolerance of various pharmacophores under the reaction conditions was also explored. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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