Cas9-AAV6-engineered human mesenchymal stromal cells improved cutaneous wound healing in diabetic mice

Autor: Waracharee Srifa, Nina Kosaric, Alvaro Amorin, Othmane Jadi, Yujin Park, Sruthi Mantri, Joab Camarena, Geoffrey C. Gurtner, Matthew Porteus
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-16065-3
Popis: Human mesenchymal stromal cells are a promising source for cell-based therapies. Here the authors use Cas9 to engineer lines that secrete PDGF-BB and VEFGA for improving wound healing.
Databáze: Directory of Open Access Journals