Chemosensory assessment and impact on quality of life in neurosensorial cluster of the post COVID 19 syndrome

Autor: Elisa Gentilotti, Anna Gorska, Maria Paola Cecchini, Massimo Mirandola, Marco Meroi, Pasquale De Nardo, Andrea Sartori, Chiara Konishi De Toffoli, Samir Kumar-Singh, Gianluigi Zanusso, Salvatore Monaco, Evelina Tacconelli, the ORCHESTRA-UNIVR Study Group
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Scientific Reports, Vol 14, Iss 1, Pp 1-14 (2024)
Druh dokumentu: article
ISSN: 2045-2322
DOI: 10.1038/s41598-024-71475-3
Popis: Abstract COVID-19 pandemic brought chemosensory impairment to the forefront of medicine, revealing gaps in the knowledge of pathophysiological mechanisms, true prevalence and preventive/therapeutic alternatives. This is a sub-study of the ORCHESTRA cohort focusing on post-COVID-19 chemosensory symptoms. Risk factors for neurosensorial cluster of post-COVID-19 syndrome (NSc-PCS) were assessed through multivariable analysis. Psychophysical validated tests were applied on a sub-population of 50 patients. Qualitative chemosensory symptoms as well as nasal and oral chemesthesis were evaluated through anamnestic interview and the quality of life through the SF-36 questionnaire. Chemosensory symptoms evolution and olfactory training’s outcome were assessed through phone-call interviews. Out of 1187 patients (female, N = 630), 550 (47%) presented NSc-PCS, with a lower risk for older age and monoclonal antibodies treatment, and a higher risk in females (p
Databáze: Directory of Open Access Journals
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