| Autor: |
Peter F.M. Teunis, Axel Bonačić Marinović, David R. Tribble, Chad K. Porter, Arno Swart |
| Jazyk: |
angličtina |
| Rok vydání: |
2018 |
| Předmět: |
|
| Zdroj: |
Epidemics, Vol 24, Iss , Pp 1-20 (2018) |
| Druh dokumentu: |
article |
| ISSN: |
1755-4365 |
| DOI: |
10.1016/j.epidem.2018.02.001 |
| Popis: |
Data from a set of different studies on the infectivity and pathogenicity of Campylobacter jejuni were analyzed with a multilevel model, allowing for effects of host species (nonhuman primates and humans) and different strains of the pathogen.All challenge studies involved high doses of the pathogen, resulting in all exposed subjects to become infected. In only one study a dose response effect (increasing trend with dose) for infection was observed. High susceptibility to infection with C. jejuni was found in a joint analysis of outbreaks and challenge studies. For that reason four outbreaks, associated with raw milk consumption, were also included in the present study.The high doses used for inoculation did not cause all infected subjects to develop acute enteric symptoms. The observed outcomes are consistent with a dose response effect for acute symptoms among infected subjects: a conditional illness dose response relation. Nonhuman primates and human volunteers did not appear to have different susceptibilities for developing enteric symptoms, but exposure in outbreaks (raw milk) did lead to a higher probability of symptomatic campylobacteriosis. Keywords: Campylobacter jejuni, Hierarchical dose response, Natural experiments, Challenge studies, Infectivity |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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