Diagnostic Challenges and Prospects Associated With Zoonotic Tuberculosis of Central Nervous System
| Autor: | Prachi R. Bapat, Seema D. Shekhawat, Aliabbas A. Husain, Renuka S. Dodkey, Hatim F. Daginawala, Lokendra K. Singh, Rajpal S. Kashyap |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Basic and Clinical Neuroscience, Vol 11, Iss 5, Pp 619-630 (2020) |
| Druh dokumentu: | article |
| ISSN: | 2008-126X 2228-7442 |
| Popis: | Introduction: The diagnosis of Tuberculous Meningitis (TBM) has remained a challenge due to its insidious onset and the failure of conventional diagnostic tests. The present study aimed to identify the mycobacterial pathogen in the CSF of patients with TBM and a poor prognosis. Methods: We retrospectively recruited 224 TBM and 34 non-TBM patients admitted to the Central India Institute of Medical Sciences, Nagpur, India, in 2014. The CSF samples of these patients were subjected to a duplex PCR assay for the species-specific identification of the causative pathogen. Results: M. bovis and infection with M.tuberculosis were detected in 7% (18) and 32.9% (85) of the patients, respectively. Moreover, 14% (36) of the study samples were culture positive; however, the mycobacterial pathogens could not be differentiated to the species level. Conclusion: The present study findings emphasized the potentially vital importance of M. bovis identification for appropriate patient management. The obtained data also demonstrated the persistent significance of M. bovis, as a zoonotic pathogen. |
| Databáze: | Directory of Open Access Journals |
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