Methodology for prediction of anticancer action of (2-oxo-2H-[1,2,4]¬triazino[2,3-c]-quinazolin-6-yl)thiones via QSAR and docking studies
| Autor: | I. S. Nosulenko, O. Yu. Voskoboynik, O. M. Antypenko, G. G. Berest, S. I. Kovalenko |
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| Jazyk: | English<br />Russian<br />Ukrainian |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Zaporožskij Medicinskij Žurnal, Iss 1, Pp 99-104 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2310-1210 2306-4145 |
| DOI: | 10.14739/2310-1210.2015.1.39873 |
| Popis: | Aimed to elaborate new group of protein kinase inhibitors we conducted receptor-based screening (docking, QSAR modeling) and biochemical testing for derivatives of (2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thiones. Methods and results. This study allowed identifying of new potential anticancer compounds among (2-oxo-2H-[1,2,4]triazino[2,3-c]quinazolin-6-yl)thiones’ derivatives. Conclusion. Obtained data may be used for the development of more active and selective inhibitors of protein CK2 kinase. Besides that QSAR-models which were created may be used for planning of chemical modification of structure aimed to creation of new anticancer agents. |
| Databáze: | Directory of Open Access Journals |
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