Domino synthetic strategy for tetrahydrothiophene derivatives from 2-acetylfuran/2-acetylthiophene, benzaldehydes, and sulfur powder

Autor:	Dongdong Chen, Yannan Bai, Qi Cheng, Jingwei Li, Zongbo Tong, Jianfeng Hou, Tao Liu, Yuqi Guo, Xiaolin Tang, Xue Yang, Xufeng Yang
Jazyk:	angličtina
Rok vydání:	2022
Předmět:	Domino reaction Tetrahydrothiophene derivatives Sulfur Powder Cyclization Benzaldehydes Chemistry QD1-999
Zdroj:	Arabian Journal of Chemistry, Vol 15, Iss 9, Pp 104097- (2022)
Druh dokumentu:	article
ISSN:	1878-5352 99221128
DOI:	10.1016/j.arabjc.2022.104097
Popis:	A domino reaction from 2-acetylfuran/2-acetylthiophene, benzaldehydes and sulfur powder has been developed to synthesize a series of tetrahydrothiophene derivatives. The reaction proceeds well to construct five new bonds and a tetrahydrothiophene ring by one-pot. A possible mechanism was proposed, involving a stepwise of Aldol/double Michael addition/internal SN2 cascaded reaction with sulfur powder acts as a source of sulfur. This method is characterized by mild reaction conditions, commercially available starting materials and transition-metal-free.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f182527a3c534b5d992211281fc466b7 Zobrazit plný text záznamu View record in DOAJ