Integrated metagenomics and metabolomics analyses revealed biomarkers in β-casein A2A2-type cows

Autor: Jinyan Zhao, Chuanchuan Wang, Jiahuan Hu, Ruoshuang Ma, Baojun Yu, Wei Zhao, Hua Wang, Yaling Gu, Juan Zhang
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Frontiers in Veterinary Science, Vol 11 (2024)
Druh dokumentu: article
ISSN: 2297-1769
DOI: 10.3389/fvets.2024.1438717
Popis: In Holstein cows, β-casein, one of the most critical proteins in milk, exists in two main genotypes, A1 and A2. Herein, 45 Holstein cows [categorized into three groups based on β-casein A1A1, A1A2, and A2A2 genotypes (N = 15)] with the same feeding management and litter size were enrolled to explore differences in rumen microflora and metabolites across various β-casein genotypes. Rumen fluids were collected for metagenomics and metabolomics analyses. Metabolomics and weighted gene co-expression network analysis (WGCNA) revealed that arachidonic acid (AA), adrenic acid (AdA), glycocholic acid (GCA), and taurocholic acid (TCA) were significantly and positively correlated with milk fat % in dairy cows (p
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