Incidental findings on brain MR imaging of asymptomatic term neonates in the Developing Human Connectome Project

Autor: Olivia Carney, Emer Hughes, Nora Tusor, Ralica Dimitrova, Sophie Arulkumaran, Kelly Pegoretti Baruteau, Alexia Egloff Collado, Lucilio Cordero-Grande, Andrew Chew, Shona Falconer, Joanna M. Allsop, Daniel Rueckert, Joseph Hajnal, A. David Edwards, Mary Rutherford
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: EClinicalMedicine, Vol 38, Iss , Pp 100984- (2021)
Druh dokumentu: article
ISSN: 2589-5370
DOI: 10.1016/j.eclinm.2021.100984
Popis: Background: Interpretation of incidental findings on term neonatal MRI brain imaging can be challenging as there is a paucity of published normative data on asymptomatic term neonates. Reporting radiologists and clinicians need to be familiar with these incidental findings to avoid over-investigation and misinterpretation particularly in relation to neurodevelopmental outcome. This study aimed to determine the prevalence of incidental findings in a large group of asymptomatic term neonates participating in the Developing Human Connectome Project (dHCP) who were invited for neurodevelopmental assessment at 18 months. Methods: We retrospectively reviewed MRI brain scans performed on 500 term neonates enrolled in the dHCP study between 2015 and 2019 with normal clinical examination. We reviewed the results of the Bayley Scales of Infant and Toddler Development (Bayley III) applied to participants who attended for neurodevelopmental follow-up at 18 months. Scores considered “delayed” if
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