| Autor: |
Jorge Arroyo-Acevedo, Oscar Herrera-Calderón, Roberto Chávez-Asmat, Andrea Anampa-Guzmán, Víctor Chumpitaz-Cerrate, Edwin Enciso-Roca |
| Jazyk: |
angličtina |
| Rok vydání: |
2017 |
| Předmět: |
|
| Zdroj: |
Prostate International, Vol 5, Iss 2, Pp 47-52 (2017) |
| Druh dokumentu: |
article |
| ISSN: |
2287-8882 |
| DOI: |
10.1016/j.prnil.2017.01.005 |
| Popis: |
Background: The main objective was to evaluate the possible protective effect of Chuquiraga spinosa extract on N-methyl nitrosourea (NMU)-induced prostate cancer in rats and DU-145 cell line. Materials and methods: Prostate carcinogenesis was induced in 30 male Holtzman rats by providing cyproterone acetate, testosterone, and NMU. The tumors were monitored and hematological and biochemical parameters and frequency of micronucleated polychromatic erythrocytes were recorded. The cell line was assessed by a cytotoxicity assay. Results: Oral administration of C. spinosa extract significantly lowered superoxide dismutase malondialdehyde, NO, C-reactive protein, and prostate-specific antigen levels (all P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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