Left ventricular global longitudinal strain predicts elevated cardiac pressures and poor clinical outcomes in patients with non-ischemic dilated cardiomyopathy

Autor: Ieva Kažukauskienė, Giedrė Balčiūnaitė, Vaida Baltrūnienė, Jelena Čelutkienė, Vytė Valerija Maneikienė, Sigitas Čibiras, Kęstutis Ručinskas, Virginija Grabauskienė
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Cardiovascular Ultrasound, Vol 19, Iss 1, Pp 1-13 (2021)
Druh dokumentu: article
ISSN: 1476-7120
DOI: 10.1186/s12947-021-00254-1
Popis: Abstract Background Risk stratification in patients with non-ischemic dilated cardiomyopathy (NI-DCM) is essential to treatment planning. Global longitudinal strain (GLS) predicts poor prognosis in various cardiac diseases, but it has not been evaluated in a cohort of exclusively NI-DCM. Although deformation parameters have been shown to reflect diastolic function, their association with other hemodynamic parameters needs further elucidation. We aimed to evaluate the association between GLS and E/GLS and invasive hemodynamic parameters and assess the prognostic value of GLS and E/GLS in a prospective well-defined pure NI-DCM cohort. Methods and results Forty-one patients with NI-DCM were enrolled in the study. They underwent a standard diagnostic workup, including transthoracic echocardiography and right heart catheterization. During a five-year follow-up, 20 (49%) patients reached the composite outcome measure: LV assist device implantation, heart transplantation, or cardiovascular death. Pulmonary capillary wedge pressure (PCWP), mean pulmonary artery pressure, pulmonary vascular resistance (PVR) correlated with GLS and E/GLS (p 3 Wood units). Survival analysis showed GLS and E/GLS to be associated with short- and long-term adverse cardiac events (p
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