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Objectives: To assess the color stability and surface roughness of resin-free and resin-based nanohybrid composites after immersion in various staining media. Methods: A resin-free ormocer composite, Admira fusion (Voco, Germany), and a methacrylate resin composite, Grandio (Voco, Germany), were used for direct composite restorations with 30 discs per material formed using a Split Teflon mold (10 mm × 2 mm). Grandio Bloc (Voco, Germany) universal indirect CAD/CAM block specimens (n = 30) were sliced to a thickness of 2 mm with a precision saw. Each material was divided into 3 groups (n = 10 each) based on the immersion solution. Specimens were soaked in coffee (Turkish coffee, Baja, Saudi Arabia), cola (Coca-Cola Co., USA), and artificial saliva. Color was evaluated before staining and after 30 days of staining using a spectrophotometer. Color change (ΔE*) was measured using the system of CIE L*a*b*. Surface roughness was determined using a stylus profilometer and represented using Atomic Force Microscopy before and after immersion in the staining solutions. Results: After immersion in the staining solutions for 30 days, the color values of all the composites changed. Group A (coffee) had the greatest effect (ΔE > 5), and indirect Grandio blocs caused the greatest color change. The surface roughness values increased, particularly in group B (Coca-Cola), for all the tested materials after 30 days. Direct Grandio had a significantly higher roughness than the other materials (p |