Impact of positron-emission tomography on the surgical treatment of locoregionally recurrent colorectal cancer

Autor: Jin-Tung Liang, Tzu-Chun Chen, Yu-Tso Liao, John Huang, Ji-Shiang Hung
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Asian Journal of Surgery, Vol 47, Iss 2, Pp 923-932 (2024)
Druh dokumentu: article
ISSN: 1015-9584
DOI: 10.1016/j.asjsur.2023.10.109
Popis: Summary: Background: The effect of positron emission tomography (PET) on the surgical treatment of locoregionally recurrent colorectal cancer (LRRCRC) remains unclear and warrants further investigation. Material and methods: A total of 193 patients with LRRCRC were identified from a prospectively maintained institutional database, of whom 134 LRRCRCs were deemed resectable and underwent resection with curative intent, whereas the remaining 59 LRRCRCs were unresectable. Patients with resectable LRRCRC were further classified according to whether recurrence was detected solely by PET (n = 35, PET-only group) or by a combination of computed tomography (CT)/magnetic resonance imaging (MRI) and PET (n = 99, CT/MRI/PET group). Clinicopathologic features, operative morbidity/mortality, and overall survival were compared between the patient groups based on long-term follow-up for at least 5 years. Results: Patients in the PET-only group tended to have less extensive organ resection (p = 0.0074), less blood loss (p 0.05) compared with the CT/MRI/PET group. Although the PET-only group had significantly higher R0 resection rate (80 % vs. 54.55 %, p = 0.0079), they also had a higher risk (17.14 % vs. 2.02 %, p = 0.0011) of sham operation. The estimated 5-year and 10-year survival rates significantly decreased in order (p
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