A New Antibiotic-Loaded Sol-Gel can Prevent Bacterial Intravenous Catheter-Related Infections
Autor: | John Jairo Aguilera-Correa, Rosa Vidal-Laso, Rafael Alfredo Carias-Cálix, Beatriz Toirac, Amaya García-Casas, Diego Velasco-Rodríguez, Pilar Llamas-Sillero, Antonia Jiménez-Morales, Jaime Esteban |
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Jazyk: | angličtina |
Rok vydání: | 2020 |
Předmět: |
catheter-related bloodstream infection
Staphylococcus epidermidis anti-infective biomaterials antibiotic-loaded sol-gel local drug delivery of moxifloxacin coagulation Technology Electrical engineering. Electronics. Nuclear engineering TK1-9971 Engineering (General). Civil engineering (General) TA1-2040 Microscopy QH201-278.5 Descriptive and experimental mechanics QC120-168.85 |
Zdroj: | Materials, Vol 13, Iss 13, p 2946 (2020) |
Druh dokumentu: | article |
ISSN: | 13132946 1996-1944 |
DOI: | 10.3390/ma13132946 |
Popis: | The aim of this study was to evaluate the effectiveness of a moxifloxacin-loaded organic–inorganic sol-gel (A50) by locally preventing the catheter-related bloodstream infection (CRBSI) provoked by Staphylococcus epidermidis (S. epidermidis) and the effect resulting from its hydrolytic degradation on coagulation by using a rabbit in-vivo model. A50 coating can completely inhibit growth and would locally prevent CRBSI provoked by S. epidermidis. None of the coagulation blood parameters showed a significant difference constant over time between the control catheter group and the A50-coated catheter group, despite the visible silica release resulting from physiological A50 sol-gel degradation detected in serum at least during the first week. At pathological level, foreign body reaction was present in both of types of catheter, and it was characterized by the presence of macrophages and foreign body giant cell. However, this reaction was different in each group: the A50-coated catheter group showed a higher inflammation with histiocytes, which were forming granuloma-like aggregates with an amorphous crystalline material inside, accompanied by other inflammatory cells such as plasma cells, lymphocytes and mast cells. In conclusion, A50 coating a venous catheter showed excellent bactericidal anti-biofilm response since it completely inhibited S. epidermidis biofilm development and, far from showing procoagulant effects, showed slightly anticoagulant effects. |
Databáze: | Directory of Open Access Journals |
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