ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation

Autor: Jessica Elmore, Chavez Carter, Amie Redko, Nicholas Koylass, Amelia Bennett, Max Mead, Marinel Ocasio-Rivera, Weishan Huang, Ankur Singh, Avery August
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-022-03109-1
Popis: The kinase Itk is normally required for differentiation of IL-17-producing CD4 T-helper (Th)17 cells however, Elmore, Carter et al. now report that Itk can be bypassed during Th17 differentiation in Saccharopolyspora rectivirgula induced hypersensitivity pneumonitis. This study suggests that some inflammatory signals can override normal T cell activation and differentiation pathways.
Databáze: Directory of Open Access Journals
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