Global Dynamics of a Delayed Fractional-Order Viral Infection Model With Latently Infected Cells

Autor: C. Rajivganthi, F. A. Rihan
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Frontiers in Applied Mathematics and Statistics, Vol 7 (2021)
Druh dokumentu: article
ISSN: 2297-4687
DOI: 10.3389/fams.2021.771662
Popis: In this paper, we propose a fractional-order viral infection model, which includes latent infection, a Holling type II response function, and a time-delay representing viral production. Based on the characteristic equations for the model, certain sufficient conditions guarantee local asymptotic stability of infection-free and interior steady states. Whenever the time-delay crosses its critical value (threshold parameter), a Hopf bifurcation occurs. Furthermore, we use LaSalle’s invariance principle and Lyapunov functions to examine global stability for infection-free and interior steady states. Our results are illustrated by numerical simulations.
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