Apolipoproteins L1 and L3 control mitochondrial membrane dynamics
Autor: | Laurence Lecordier, Paul Heo, Jonas H. Graversen, Dorle Hennig, Maria Kløjgaard Skytthe, Alexandre Cornet d’Elzius, Frédéric Pincet, David Pérez-Morga, Etienne Pays |
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Jazyk: | angličtina |
Rok vydání: | 2023 |
Předmět: | |
Zdroj: | Cell Reports, Vol 42, Iss 12, Pp 113528- (2023) |
Druh dokumentu: | article |
ISSN: | 2211-1247 14274957 |
DOI: | 10.1016/j.celrep.2023.113528 |
Popis: | Summary: Apolipoproteins L1 and L3 (APOLs) are associated at the Golgi with the membrane fission factors phosphatidylinositol 4-kinase-IIIB (PI4KB) and non-muscular myosin 2A. Either APOL1 C-terminal truncation (APOL1Δ) or APOL3 deletion (APOL3-KO [knockout]) reduces PI4KB activity and triggers actomyosin reorganization. We report that APOL3, but not APOL1, controls PI4KB activity through interaction with PI4KB and neuronal calcium sensor-1 or calneuron-1. Both APOLs are present in Golgi-derived autophagy-related protein 9A vesicles, which are involved in PI4KB trafficking. Like APOL3-KO, APOL1Δ induces PI4KB dissociation from APOL3, linked to reduction of mitophagy flux and production of mitochondrial reactive oxygen species. APOL1 and APOL3, respectively, can interact with the mitophagy receptor prohibitin-2 and the mitophagosome membrane fusion factor vesicle-associated membrane protein-8 (VAMP8). While APOL1 conditions PI4KB and APOL3 involvement in mitochondrion fission and mitophagy, APOL3-VAMP8 interaction promotes fusion between mitophagosomal and endolysosomal membranes. We propose that APOL3 controls mitochondrial membrane dynamics through interactions with the fission factor PI4KB and the fusion factor VAMP8. |
Databáze: | Directory of Open Access Journals |
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