A randomized comparative study of efficacy of microneedling with 5% 5-FU and microneedling with 0.1% tacrolimus in treatment of vitiligo
| Autor: | Shanta Passi, Snehlata Punia, Garima Vinayak |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2023 |
| Předmět: | |
| Zdroj: | Pigment International, Vol 10, Iss 3, Pp 148-152 (2023) |
| Druh dokumentu: | article |
| ISSN: | 2349-5782 2349-5847 |
| DOI: | 10.4103/pigmentinternational.pigmentinternational_17_22 |
| Popis: | Background: Vitiligo is an amelanotic disorder affecting 0.5% to 2% of the world’s population. Several treatment modalities have been tried and it has been reported that combination therapies augment the repigmentation in vitiligo. Objective: To compare the efficacy of microneedling with 5% 5-FU and microneedling with 0.1% tacrolimus in treatment of vitiligo. Methods: Twenty-five patients with localized stable vitiligo were subjected to microneedling of two patches with dermaroller of size 2 mm, then application of 5-fluorouracil to one patch and tacrolimus on the other patch. This procedure was repeated every month for maximum 6 months (six sessions). The patients were followed up for 3 to 4 months after the last session. Results: The overall repigmentation was slightly higher in 5-FU treated patches than tacrolimus treated patches. Very much improved to much improvement in VASI score was seen in 14 patches (64%) in 5% 5FU treated patches and 11 patches (44%) in 0.1% tacrolimus treated patches. Improved and minimally improved lesions, that is, eight patches (32%) and 11 patches (44%) respectively treated with 5% 5FU and 0.1% tacrolimus. Three patients (12%) showed no improvement. However, there was significant difference between the two drugs, regarding inflammation, ulceration, and hyperpigmentation which occurred with 5-FU. Conclusion: Microneedling combined with 5% 5-fluorouracil or tacrolimus is effective though 5-FU achieved better repigmentation. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|