| Autor: |
Roman Labuda, Markus Bacher, Hannes Gratzl, Maria Doppler, Alexandra Parich, Mohammed Aufy, Rosa Lemmens-Gruber, Rainer Schuhmacher, Kathrin Rychli, Martin Wagner, Thomas Rosenau, Joseph Strauss, Christoph Schüller |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Molecules, Vol 26, Iss 21, p 6589 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
1420-3049 |
| DOI: |
10.3390/molecules26216589 |
| Popis: |
In the process of screening for new bioactive microbial metabolites we found a novel ƴ-pyrone derivative for which we propose the trivial name luteapyrone, in a recently described microscopic filamentous fungus, Metapochonia lutea BiMM-F96/DF4. The compound was isolated from the culture extract of the fungus grown on modified yeast extract sucrose medium by means of flash chromatography followed by preparative HPLC. The chemical structure was elucidated by NMR and LC-MS. The new compound was found to be non-cytotoxic against three mammalian cell lines (HEK 263, KB-3.1 and Caco-2). Similarly, no antimicrobial activity was observed in tested microorganisms (gram positive and negative bacteria, yeast and fungi). |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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