Molecular features of glioblastomas in long-term survivors compared to short-term survivors—a matched-pair analysis

Autor: Vivien N. Sommerlath, Daniel Buergy, Nima Etminan, Stefanie Brehmer, David Reuss, Gustavo R. Sarria, Marie-Christin Guiot, Daniel Hänggi, Frederik Wenz, Kevin Petrecca, Frank A. Giordano
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Radiation Oncology, Vol 17, Iss 1, Pp 1-8 (2022)
Druh dokumentu: article
ISSN: 1748-717X
DOI: 10.1186/s13014-022-01984-w
Popis: Abstract Background Although glioblastoma (GB) is associated with a devastating prognosis, a small proportion of patients achieve long-term survival rates. We herein present a matched-pair analysis of molecular factors found in long- and short-term survivors (LTS, STS). Methods We performed a cross-institutional analysis of 262 patient records and matched a group of 91 LTS (≥ 3 years) with two groups of STS (STS-1, n = 91; STS-2, n = 80). Matching was performed according to age, Karnofsky Performance Status, initial therapy and adjuvant therapy. Molecular factors were compared between LTS (total of 91 patients) v. STS-1, and LTS (subgroup of 80 patients) v. STS-2. We included glial fibrillary acidic protein (GFAP), O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation, isocitrate dehydrogenase 1 (IDH-1); furthermore, the proliferation index was analyzed (Ki-67/MIB-1). Results IDH-1 and decreased Ki-67 were numerically associated with LTS but the difference was only significant compared to STS-1 (n.s. v. STS-2). LTS was associated with MGMT promoter hypermethylation (p = 0.013 and p = 0.022) and GFAP expression (p
Databáze: Directory of Open Access Journals
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje