Facile One-Pot Synthesis and Anti-Microbial Activity of Novel 1,4-Dihydropyridine Derivatives in Aqueous Micellar Solution under Microwave Irradiation

Autor:	Asmita Goswami, Navneet Kaur, Manvinder Kaur, Kishanpal Singh, Harvinder Singh Sohal, Haesook Han, Pradip K. Bhowmik
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	multi-component reaction 1 4-dihydropyridines microwave heterocyclic compounds Al(DS)3 green synthesis Organic chemistry QD241-441
Zdroj:	Molecules, Vol 29, Iss 5, p 1115 (2024)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules29051115
Popis:	The current study describes a novel and eco-conscious method to synthesize 1,4-dihydropyridine derivatives utilizing an aqueous micellar solution containing aluminum dodecyl sulfate, Al(DS)3, using readily available starting material. The final products were synthesized with excellent yields within remarkably quick reaction durations, promoting remarkable atom economy and minimizing environmental impacts. The present protocol has several advantages over other methodologies in terms of high yield (up to 97%) with excellent purity. Further, the synthesized 1,4-DHPs exhibit favorable to excellent resistance against examined bacterial and fungal species. Intriguingly, polar groups on the phenyl ring (5b, 5c, 5i and 5j) make the 1,4-DHPs equally potent against the microbes as compared to the standard drugs.
Databáze:	Directory of Open Access Journals
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