Meta analysis of allele and genotype frequency of growth hormone (bgh) gene alui polymorphism, which is effective on milk yield in holstein cattle

Autor: Aytaç AKÇAY, Fadime DALDABAN, Elif ÇELİK, Korhan ARSLAN, Bilal AKYÜZ
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Kafkas Universitesi Veteriner Fakültesi Dergisi, Vol 26, Iss 5, Pp 687-695 (2020)
Druh dokumentu: article
ISSN: 1309-2251
DOI: 10.9775/kvfd.2020.24256
Popis: There are studies investigating the relationship between bGH gene AluI polymorphism and milk yield in bovine breeds. In the presented study, the relationship between different genotypes and lactation milk yields was determined by analyzing bGH-AluI genotype and allele frequencies in Holstein breed by meta-analysis method. The study material consisted of studies investigating bGH-AluI polymorphisms that are effective on milk yield in Holstein breed. According to the determined criteria, allele and genotype frequencies of 4583 samples in 20 studies selected from 35 studies and milk yields of 932 samples in 6 studies in which milk yields were calculated according to genotypes were included in the meta analysis. In the study, meta analyzes LL, LV and VV genotypes and L and V alleles and lactation milk yields were performed for bGH gene. The study samples were proved to be unbiased with the Begg and Mazumdar Rank Correlations test and funnel plot. As a result of the study, high heterogeneity was determined between the investigated studies concerning all genotypes (LL, LV and VV) and allele frequencies (L and V), thus random effect model was used. Meta analyzes were done with Comprehensive Meta-Analysis Software (CMA). According to the random effect model, pooled ratios in LL, LV and VV genotypes are 0.710, 0.260 and 0.030; pooled ratios for L and V allele frequencies were calculated as 0.818 and 0.182 and were found statistically significant (P
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