K2CO3-Mediated Synthesis of Functionalised 4-Substituted-2-amino-3-cyano-4H-chromenes via Michael-Cyclization Reactions

Autor: Yanyang He, Rong Hu, Rongsheng Tong, Fengqiong Li, Jianyou Shi, Mei Zhang
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Molecules, Vol 19, Iss 12, Pp 19253-19268 (2014)
Druh dokumentu: article
ISSN: 1420-3049
DOI: 10.3390/molecules191219253
Popis: An efficient approach for the synthesis of functionalized 4-substituted-2-amino-3-cyano-4H-chromenes moderate to high yields (up to 98%) has been achieved via a tandem K2CO3 catalyzed conjugate addition-cyclization reaction of malononitrile and a range of Knoevenagel adducts previously formed from oxindole, pyrazolone, nitromethane, N,N-dimethylbarbituric acid or indanedione. This methodology differs from the previous classical methods in its simplicity and ready availability of the catalyst.
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