| Autor: |
Varduhi Petrosyan, Lacey E. Dobrolecki, Emily L. LaPlante, Ramakrishnan Rajaram Srinivasan, Matthew H. Bailey, Alana L. Welm, Bryan E. Welm, Michael T. Lewis, Aleksandar Milosavljevic |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
npj Breast Cancer, Vol 8, Iss 1, Pp 1-5 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2374-4677 |
| DOI: |
10.1038/s41523-022-00476-0 |
| Popis: |
Abstract TNBC is a heterogeneous subtype of breast cancer, and only a subset of TNBC can be established as PDXs. Here, we show that there is an engraftment bias toward TNBC with low levels of immune cell infiltration. Additionally, TNBC that failed to engraft show gene expression consistent with a cancer-promoting immunological state, leading us to hypothesize that the immunological state of the tumor and possibly the state of the immune system of the host may be essential for engraftment. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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