| Autor: |
Tze Ping Loh, Lieng Hsi Ling, Anselm Mak, Lingli Gong, Nien Yee Kow, Chun En Yau, Sen Hee Tay, Ainsley Ryan Yan Bin Lee, Cheryl Kai Ting Chua, Wan Ling Cheng, Avery Joy Li Chia, Shi Yin Wong, Bernett Teck Kwong Lee |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
Lupus Science and Medicine, Vol 11, Iss 1 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2053-8790 |
| DOI: |
10.1136/lupus-2023-001030 |
| Popis: |
Objective Patients with systemic lupus erythematosus (SLE) have increased risk of premature atherosclerosis but the exact mechanisms remains unclear. Flow-mediated dilatation (FMD) is an established non-invasive assessment of vascular endothelial function. Lipoprotein subfractions may be better predictors of FMD than conventional cholesterol measurements. We tested the hypothesis that lipoprotein subfractions are independently associated with FMD.Methods Forty-one consecutive adult patients with SLE without known cardiovascular risk factors or disease were recruited in this cross-sectional study. Endothelial function and early atherosclerosis were assessed by brachial FMD and common carotid artery (CCA) intima-media thickness (IMT). High-density lipoprotein (HDL)/low-density lipoprotein (LDL) subfractions were measured. Machine learning models were also constructed to predict FMD and CCA IMT.Results Median FMD was 4.48% (IQR 5.00%) while median IMT was 0.54 mm (IQR 0.12 mm). Univariate analysis showed lower LDL1 (r=−0.313, p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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