Pneumococcal colonization prevalence and density among Thai children with severe pneumonia and community controls.

Autor: Barameht Piralam, Christine Prosperi, Somsak Thamthitiwat, Charatdao Bunthi, Pongpun Sawatwong, Ornuma Sangwichian, Melissa M Higdon, Nora L Watson, Maria Deloria Knoll, Wantana Paveenkittiporn, Chuwattana Chara, Cameron P Hurst, Pasakorn Akarasewi, Julia Rhodes, Susan A Maloney, Katherine L O'Brien, Henry C Baggett
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: PLoS ONE, Vol 15, Iss 4, p e0232151 (2020)
Druh dokumentu: article
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0232151
Popis: BACKGROUND:Pneumococcal colonization prevalence and colonization density, which has been associated with invasive disease, can offer insight into local pneumococcal ecology and help inform vaccine policy discussions. METHODS:The Pneumonia Etiology Research for Child Health Project (PERCH), a multi-country case-control study, evaluated the etiology of hospitalized cases of severe and very severe pneumonia among children aged 1-59 months. The PERCH Thailand site enrolled children during January 2012-February 2014. We determined pneumococcal colonization prevalence and density, and serotype distribution of colonizing isolates. RESULTS:We enrolled 224 severe/very severe pneumonia cases and 659 community controls in Thailand. Compared to controls, cases had lower colonization prevalence (54.5% vs. 62.5%, p = 0.12) and lower median colonization density (42.1 vs. 210.2 x 103 copies/mL, p
Databáze: Directory of Open Access Journals
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