Different fetal-neonatal outcomes in siblings born to a mother with Graves-Basedow disease after total thyroidectomy: a case series

Autor: De Carolis Maria, Papacci Patrizia, Cota Francesco, Alighieri Giovanni, Antichi Eleonora, Carducci Chiara, Perrone Sabrina, Sindico Paola, Zuppa Antonio, Romagnoli Costantino, Cardiello Valentina
Jazyk: angličtina
Rok vydání: 2010
Předmět:
Zdroj: Journal of Medical Case Reports, Vol 4, Iss 1, p 59 (2010)
Druh dokumentu: article
ISSN: 1752-1947
DOI: 10.1186/1752-1947-4-59
Popis: Abstract Introduction We describe three different fetal or neonatal outcomes in the offspring of a mother who had persistent circulating thyrotropin receptor antibodies despite having undergone a total thyroidectomy several years before. Case presentation The three different outcomes were an intrauterine death, a mild and transient fetal and neonatal hyperthyroidism and a severe fetal and neonatal hyperthyroidism that required specific therapy. Conclusions The three cases are interesting because of the different outcomes, the absence of a direct correlation between thyrotropin receptor antibody levels and clinical signs, and the persistence of thyrotropin receptor antibodies several years after a total thyroidectomy.
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