Endothelial microRNAs in INOCA patients with diabetes mellitus

Autor: Marco Ferrone, Michele Ciccarelli, Fahimeh Varzideh, Urna Kansakar, Germano Guerra, Federica Andrea Cerasuolo, Antonietta Buonaiuto, Antonella Fiordelisi, Enzo Venga, Mafalda Esposito, Antonio Rainone, Roberto Ricciardi, Carmine Del Giudice, Fabio Minicucci, Tullio Tesorio, Valeria Visco, Guido Iaccarino, Jessica Gambardella, Gaetano Santulli, Pasquale Mone
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Cardiovascular Diabetology, Vol 23, Iss 1, Pp 1-7 (2024)
Druh dokumentu: article
ISSN: 1475-2840
DOI: 10.1186/s12933-024-02331-x
Popis: Abstract Ischemia with non-obstructive coronary artery (INOCA) is a common cause of hospital admissions, leading to negative outcomes and reduced quality of life. Central to its pathophysiology is endothelial dysfunction, which contributes to myocardial ischemia despite the absence of significant coronary artery blockage. Addressing endothelial dysfunction is essential in managing INOCA to alleviate symptoms and prevent cardiovascular events. Recent studies have identified diabetes mellitus (DM) as a significant factor exacerbating INOCA complications by promoting endothelial impairment and coronary microvascular dysfunction. MicroRNAs (miRNAs) have emerged as potential biomarkers and therapeutic targets in various biological processes, including endothelial dysfunction and cardiovascular diseases. However, research on miRNA biomarkers in INOCA patients is sparse. In this study, we examined a panel of circulating miRNAs involved in the regulation of endothelial function in INOCA patients with and without DM. We analyzed miRNA expression using RT-qPCR in a cohort of consecutive INOCA patients undergoing percutaneous coronary intervention. We detected a significant dysregulation of miR-363-5p and miR-92a-3p in INOCA patients with DM compared to those without DM, indicating their role as biomarkers for predicting and monitoring endothelial dysfunction in INOCA patients with DM.
Databáze: Directory of Open Access Journals
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