Targeting protein folding in N‐Myc‐driven medulloblastoma

Autor:	Gintvile Valinciute, Martine F. Roussel
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	chaperones EIF4E Hsp70 medulloblastoma N‐Myc protein translation Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Molecular Oncology, Vol 17, Iss 3, Pp 387-389 (2023)
Druh dokumentu:	article
ISSN:	1878-0261 1574-7891
DOI:	10.1002/1878-0261.13395
Popis:	Selective targeting of N‐Myc‐driven Sonic hedgehog (SHH) medulloblastoma has been a challenge for many years and, despite decades of research, few targeted therapy opportunities exist. Recently, Kuzuoglu‐Ozturk et al. characterized the translatome of N‐Myc‐driven medulloblastoma as a promising therapeutic target. The study showed that N‐Myc controls a subset of members of the protein folding machinery that could be inhibited pharmacologically and validated a subset of Hsp70 functions as required for medulloblastoma progression in vitro and in vivo.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/f102d6a5115c45fe80f98b70c14330dc Zobrazit plný text záznamu Plný text View record in DOAJ