Mechanism of action of mRNA-based vaccines

Autor:	Carlo Iavarone, Derek T. O’hagan, Dong Yu, Nicolas F. Delahaye, Jeffrey B. Ulmer
Jazyk:	angličtina
Rok vydání:	2017
Předmět:	intrinsic adjuvanticity innate immunity antiviral response type i interferon delivery system optimization self-amplifying mrna (sam) Internal medicine RC31-1245
Zdroj:	Expert Review of Vaccines, Vol 16, Iss 9, Pp 871-881 (2017)
Druh dokumentu:	article
ISSN:	1476-0584 1744-8395 14760584
DOI:	10.1080/14760584.2017.1355245
Popis:	Introduction: The present review summarizes the growing body of work defining the mechanisms of action of this exciting new vaccine technology that should allow rational approaches in the design of next generation mRNA vaccines. Areas covered: Bio-distribution of mRNA, localization of antigen production, role of the innate immunity, priming of the adaptive immune response, route of administration and effects of mRNA delivery systems. Expert commentary: In the last few years, the development of RNA vaccines had a fast growth, the rising number of proof will enable rational approaches to improving the effectiveness and safety of this modern class of medicine.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/af0fd2c6700e471485016843d9b2aaab Zobrazit plný text záznamu View record in DOAJ