SYM 2206 (a potent non-competitive AMPA receptor antagonist) elevates the threshold for maximal electroshock-induced seizures in mice
| Autor: | Luszczki Jarogniew J., Leszkowicz Magdalena, Kondrat-Wrobel Maria W., Florek-Luszczki Magdalena |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Current Issues in Pharmacy and Medical Sciences, Vol 27, Iss 2, Pp 80-83 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2084-980X 2300-6676 |
| DOI: | 10.2478/cipms-2014-0018 |
| Popis: | The aim of this study was to determine the effect of SYM 2206 (a potent non-competitive AMPA receptor antagonist) on the threshold for maximal electroshock (MEST)-induced seizures in mice. Electroconvulsions were produced in mice by means of a current (sinewave, 50 Hz, maximum 500 V, strength from 4 to 14 mA, 0.2-s stimulus duration, tonic hind limb extension taken as the endpoint) delivered via ear-clip electrodes. SYM 2206 administered systemically (i.p.), 30 min before the MEST test, at doses of 2.5 and 5 mg/kg, did not alter the threshold for maximal electroconvulsions in mice. In contrast, SYM 2206 at doses of 10 and 20 mg/kg significantly elevated the threshold for maximal electroconvulsions in mice (P |
| Databáze: | Directory of Open Access Journals |
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