| Autor: |
Anders Bertil Rodell, Joel Frederik Aanerud, Hans eBraendgaard, Albert eGjedde |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
|
| Zdroj: |
Frontiers in Aging Neuroscience, Vol 5 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1663-4365 |
| DOI: |
10.3389/fnagi.2013.00045 |
| Popis: |
Rapid clearance and disappearance of a tracer from the circulation challenges the determination of thetracer’s binding potentials in brain (BPND ) by positron emission tomography (PET). This is the casefor the analysis of the binding of radiolabeled [11 C]Pittsburgh Compound B ([11 C]PIB) to amyloid-β(Aβ) plaques in brain of patients with Alzheimer’s disease (AD). To resolve the issue of rapid clearancefrom the circulation, we here introduce the flow-independent Washout Allometric Reference Method(Warm) for the analysis of washout and binding of [11 C]PIB in two groups of human subjects, healthyaged control subjects (HC), and patients suffering from AD, and we compare the results to the outcomeof two conventional analysis methods. We also use the rapid initial clearance to obtain a surrogatemeasure of the rate of cerebral blood flow (CBF), as well as a method of identifying a suitable referenceregion directly from the [11 C]PIB signal. The difference of average absolute CBF values between theAD and HC groups was highly significant (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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