Multiplexed imaging analysis of the tumor-immune microenvironment reveals predictors of outcome in triple-negative breast cancer

Autor: Aalok Patwa, Rikiya Yamashita, Jin Long, Tyler Risom, Michael Angelo, Leeat Keren, Daniel L. Rubin
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Druh dokumentu: article
ISSN: 2399-3642
DOI: 10.1038/s42003-021-02361-1
Popis: Patwa, Yamashita et al. utilize multiplexed imaging to demonstrate that profiling cell-to-cell interactions in the microenvironment can reveal predictors of recurrence and overall survival in triple-negative breast cancer, especially highlighting the relevance of immunoregulatory proteins. The authors also use multivariate analysis to provide additional prognostic information compared to clinical variables.
Databáze: Directory of Open Access Journals