Polyoxygenated Diterpene Produced by The Indonesian Marine Sponge Callyspongiasp. as an Inhibitor of the Human Pancreatic Cancer Cells
| Autor: | VIQQI KURNIANDA, SUCI FARADILLA, SOFYATUDDIN KARINA, SRI AGUSTINA, MARIA ULFAH, CHITRA OCTAVINA, FARAH SYAHLIZA, MUHAMMAD RIZKI RAMADHAN, SYAHRUL PURNAWAN, MUSRI MUSMAN |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | Microbiology Indonesia, Vol 13, Iss 2 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1978-3477 2087-8575 |
| DOI: | 10.5454/mi.13.2.5 |
| Popis: | The bioactive compound from the Indonesian Marine SpongeCallyspongia sp.isolated based on bioassay-guided separation with several steps of chromatography has been done. There are 4 major compound known as isocopalane diterpene derivatives together with a plausible new compound, isocopalanol, a polyoxygenated isocopalane diterpene. Isocopalanol has molecular weight [M+H]+ 412.576 m/z indicate that the compound has molecular formula C24H44O5 determined by LCMS-ESI. This compound has bioactivity IC50 = 0.1 μg / mL against human pancreatic cancer cell. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|