Potential prognostic value of miR-132 and miR-212 expression in mCRPC patients
| Autor: | Mariano Pontico, Viviana Frantellizzi, Luca Cindolo, Giuseppe De Vincentis |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: | |
| Zdroj: | Archivio Italiano di Urologia e Andrologia, Vol 93, Iss 3 (2021) |
| Druh dokumentu: | article |
| ISSN: | 1124-3562 2282-4197 |
| DOI: | 10.4081/aiua.2021.3.373 |
| Popis: | To the Editor, we have been very pleased to read the interesting work proposed by Salemi et al. regarding the expression of specific fragments of microRNA (miRNA), particularly miR-132 and miR-212, as potential key regulators in prostate cancer (PCa). As outlined by the Authors, the altered expression of miRNAs in cancer pathogenesis represents a well-consolidated knowledge in the current literature. More specifically, both miR-212 and miR-132 regulate subsets of genes involved in tumor progression in several tumor cell types as PCa, proving a central role in tumorigenesis, cell adhesion, and angiogenesis. In addition, a strong association between miR-132 expression and high Gleason score PCa has been lately depicted [...]. |
| Databáze: | Directory of Open Access Journals |
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