Benzothiazole‐endoperoxide conjugates protect PC12 cells against β‐amyloid‐induced cell death via singlet oxygen mediated oxidative detoxification of fibrils

Autor:	Hao Wu, Lei Wang, Xiao Qian, Wanwan Wang, Yu Si, Rensong Sun, Engin U. Akkaya
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	β‐amyloid protein Alzheimer's disease benzothiazole endoperoxides singlet oxygen Chemistry QD1-999
Zdroj:	Smart Molecules, Vol 2, Iss 2, Pp n/a-n/a (2024)
Druh dokumentu:	article
ISSN:	2751-4595 2751-4587
DOI:	10.1002/smo.20230019
Popis:	Abstract Metastable endoperoxides with beta‐amyloid fibrils targeting benzothiazole moieties were designed and synthesized. Singlet oxygen released from these endoperoxides by thermal cycloreversion reaction was shown to cause significant structural changes on the amyloid assemblies. Most importantly, the cytotoxicity of the beta‐amyloid fibrils on the PC12 cells were significantly reduced in the presence of endoperoxides. This observation, coupled with the fact that neither external oxygen, nor light is needed for this transformation, is very promising.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/df0c3f1e99b543af903fcfb88712add7 Zobrazit plný text záznamu Plný text View record in DOAJ