| Autor: |
Georgi Apriamashvili, David W. Vredevoogd, Oscar Krijgsman, Onno B. Bleijerveld, Maarten A. Ligtenberg, Beaunelle de Bruijn, Julia Boshuizen, Joleen J. H. Traets, Daniela D’Empaire Altimari, Alex van Vliet, Chun-Pu Lin, Nils L. Visser, James D. Londino, Rebekah Sanchez-Hodge, Leah E. Oswalt, Selin Altinok, Jonathan C. Schisler, Maarten Altelaar, Daniel S. Peeper |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2041-1723 |
| DOI: |
10.1038/s41467-022-29442-x |
| Popis: |
The IFNγ response pathway is associated with response to immunotherapy in cancer. Here the authors show that high levels of the IFNγ-receptor (IFNγ-R1) affect the outcome of immunotherapy in a context-dependent fashion and identify the E3 ubiquitin ligase STUB1 as a negative regulator of IFNγ-R1/JAK1 expression in cancer cells. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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