| Autor: |
Roberta Marchiori, Carla Sakuma de Oliveira Bredt, Marcos Menezes Freitas de Campos, Fábio Negretti, Péricles Almeida Delfino Duarte |
| Jazyk: |
English<br />Portuguese |
| Rok vydání: |
2012 |
| Předmět: |
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| Zdroj: |
Einstein (São Paulo), Vol 10, Iss 3, Pp 306-311 (2012) |
| Druh dokumentu: |
article |
| ISSN: |
1679-4508 |
| Popis: |
Objective: To analyze the histopathological lung findings of four fatal cases of the 2009 H1N1 influenza pandemic and their correlation with clinical and epidemiological characteristics. Methods: descriptive data from medical records of four patients who died in the Intensive Care Unit of a university hospital in 2009. Nasopharyngeal aspirate specimens were collected from the patients and were analyzed by real-time polymerase chain reaction. Lung biopsy was performed post mortem; a score of intensity for pathological changes was applied. Results: Three patients had positive real-time polymerase chain reaction (although all of them had a clinical diagnose of influenza H1N1). The main histopathological changes were: exudative diffuse alveolar damage with atelectasis; varying degrees of alveolar hemorrhage and edema, necrosis and sloughing of the respiratory epithelium in several bronchioli; and thrombus formation. One of the patients (the pregnant one) presented histopathological findings of cytomegalic inclusion. Conclusion: The pulmonary histopathological findings in patients with fatal 2009 H1N1 influenza pandemic disclosed intense alveolar damage and hemorrhage and severebronchiolitis. A co-infection with cytomegalovirus was described inthe pregnant patient. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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