| Autor: |
Sherif A. El-Kafrawy, Ahmed M. Hassan, Mai M. El-Daly, Mohammed Al-Hajri, Elmoubashar Farag, Fatimah Ahmed Elnour, Anas Khan, Ahmed M. Tolah, Thamir A. Alandijany, Noura A. Othman, Ziad A. Memish, Victor M. Corman, Christian Drosten, Alimuddin Zumla, Esam I. Azhar |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Scientific Reports, Vol 12, Iss 1, Pp 1-7 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2045-2322 |
| DOI: |
10.1038/s41598-022-11208-6 |
| Popis: |
Abstract Camels gained attention since the discovery of MERS-CoV as intermediary hosts for potentially epidemic zoonotic viruses. DcHEV is a novel zoonotic pathogen associated with camel contact. This study aimed to genetically characterize DcHEV in domestic and imported camels in Saudi Arabia. DcHEV was detected by RT-PCR in serum samples, PCR-positive samples were subjected to sequencing and phylogenetic analyses. DcHEV was detected in 1.77% of samples with higher positivity in domestic DCs. All positive imported dromedaries were from Sudan with age declining prevalence. Domestic DcHEV sequences clustered with sequences from Kenya, Somalia, and UAE while imported sequences clustered with one DcHEV isolate from UAE and both sequences clustered away from isolates reported from Pakistan. Full-genome sequences showed 24 amino acid difference with reference sequences. Our results confirm the detection of DcHEV in domestic and imported DCs. Further investigations are needed in human and camel populations to identify DcHEV potential zoonosis threat. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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